THE 2-MINUTE RULE FOR AMORPHOUS SOLID DISPERSION DEVELOPMENT

g and results in a plasticizing effect which improves the molecular mobility of ASD and the chance of crystallization. Absorbed h2o might also probably disrupt the drug-polymer interactions by competing with hydrophilic polymers for hydrogen bond formation64. For sure ASD devices, extra moisture might also lessen the drug-polymer solubility65,66. o